Tamara Thomas

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People with atopic dermatitis or asthma may be at a higher risk for developing osteoarthritis—signaling an allergic pathway might be involved—according to a recent study published in the Annals of the Rheumatic Diseases. 
Dr. William Baker and his team at Stanford University conducted a study to see if people with certain conditions, such as asthma and atopic dermatitis, were more likely to develop osteoarthritis. The researchers observed the Clinformatics Data Mart database between January 2003 and June 2019. They compared a group of 117,346 exposed individuals to a control group of 1,247,196 individuals. The exposed individuals had asthma, atopic dermatitis, or both.
The researchers found that the risk of osteoarthritis was higher for patients with asthma or eczema than for unexposed patients. Specifically, the study showed that if a patient had asthma or eczema, there was a 58% increased risk of developing osteoarthritis over 10 years. If they had asthma and eczema, the risk increased to 115%.
To be certain that allergens mediated the association of osteoarthritis, the researchers compared the effect to patients with chronic obstructive pulmonary disease (COPD), a lung disease not mediated by allergens. They found that patients with asthma had an 83% increased risk of developing osteoarthritis compared with COPD patients.
The researchers observed that since lung disease without an allergic response does not increase the risk of osteoarthritis, the activation of allergic pathways must play a role in the development of osteoarthritis.
In conclusion, further understanding of the allergic pathways involved could help prevent and treat osteoarthritis.
“The main takeaway of our study is that we found an association between having allergic diseases such as asthma and atopic dermatitis and having an increased risk of developing osteoarthritis. Before this study, our group has done work showing that mast cells (a type of allergic cell) are increased in numbers in the joints of people with osteoarthritis, and their activity contributes to the development of osteoarthritis. Our current study provides epidemiological support for this observation,” Dr. Baker wrote.
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Source: <a href="https://www.medicalnewstoday.com/articles/atopic-dermatitis-allergic-atopic-asthma-eczema-linked-to-heightened-risk-of-osteoarthritis" target="_blank" rel="noopener">Medical News</a>

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Asthma, Eczema Associated With Increased Risk of Osteoarthritis

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A recent study suggests that individuals with atopic dermatitis or asthma have a higher risk of developing osteoarthritis.

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