Tamara Thomas

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According to a study published in Cancer Discovery, there is a significantly higher rate of high-risk histologic and molecular endometrial cancer subtypes in Black women compared to those of other races.
Studies have shown that Black and White women develop endometrial carcinoma at similar rates. However, stark racial disparities exist in mortality rates, with Black women experiencing a significantly higher death rate from the disease.
For this study, Dr. Britta Weigelt and colleagues analyzed 1882 patients with endometrial cancer. Of these patients, 259 self-identified as Black and 1623 as White patients.
The study demonstrated that Black and White endometrial cancer patients have different genetic, histologic, and molecular changes. The researchers found that Black patients more commonly had endometrial cancer of high-risk histology that was more aggressive than the type more commonly found in White women.
According to Dr. Weigelt and colleagues, the tumors of Black women are less likely to be of a molecular subtype called microsatellite instability-high (MSI-H), a subtype beneficial to some forms of immunotherapy. The researchers also revealed that Black patients had other key factors that made their cancers both higher risk and more difficult to treat. 
One such factor is a molecular subtype of endometrial cancer called copy number-high or TP53 abnormal (CN-H/TP53abn). According to Dr. Weigelt, having this molecular subtype might be linked to a poorer prognosis. Specifically, the researchers found that almost 70% of Black patients had this high-risk molecular subtype of endometrial cancer, as opposed to only 35% of White patients.
“Our data suggest, collectively, that Black patients may have differential access to immune-based therapies compared with White patients, as their tumors less commonly have molecular subtypes or markers that confer the most benefit.” the researchers concluded.
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Source: <a href="https://www.mskcc.org/news/endometrial-cancer-new-insights-into-deadly-disparity">Memorial Sloan Kettering Cancer News</a>
Journal source: <a href="https://aacrjournals.org/cancerdiscovery/article/13/11/2356/729849/Molecular-Characterization-of-Endometrial">Cancer Discovery</a>

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Researchers found that Black patients more commonly had endometrial cancer of high-risk histology that was more aggressive than found in White women.

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