Tamara Thomas

AZUHT-PRODUCTIONwarmup

According to a study published in Cancer Discovery, there is a significantly higher rate of high-risk histologic and molecular endometrial cancer subtypes in Black women compared to those of other races.
Studies have shown that Black and White women develop endometrial carcinoma at similar rates. However, stark racial disparities exist in mortality rates, with Black women experiencing a significantly higher death rate from the disease.
For this study, Dr. Britta Weigelt and colleagues analyzed 1882 patients with endometrial cancer. Of these patients, 259 self-identified as Black and 1623 as White patients.
The study demonstrated that Black and White endometrial cancer patients have different genetic, histologic, and molecular changes. The researchers found that Black patients more commonly had endometrial cancer of high-risk histology that was more aggressive than the type more commonly found in White women.
According to Dr. Weigelt and colleagues, the tumors of Black women are less likely to be of a molecular subtype called microsatellite instability-high (MSI-H), a subtype beneficial to some forms of immunotherapy. The researchers also revealed that Black patients had other key factors that made their cancers both higher risk and more difficult to treat. 
One such factor is a molecular subtype of endometrial cancer called copy number-high or TP53 abnormal (CN-H/TP53abn). According to Dr. Weigelt, having this molecular subtype might be linked to a poorer prognosis. Specifically, the researchers found that almost 70% of Black patients had this high-risk molecular subtype of endometrial cancer, as opposed to only 35% of White patients.
“Our data suggest, collectively, that Black patients may have differential access to immune-based therapies compared with White patients, as their tumors less commonly have molecular subtypes or markers that confer the most benefit.” the researchers concluded.
&nbsp;
Source: <a href="https://www.mskcc.org/news/endometrial-cancer-new-insights-into-deadly-disparity">Memorial Sloan Kettering Cancer News</a>
Journal source: <a href="https://aacrjournals.org/cancerdiscovery/article/13/11/2356/729849/Molecular-Characterization-of-Endometrial">Cancer Discovery</a>

Katie Kosko

How Racial Disparities in Penile Cancer Affect Patient Outcomes

SUO 2024

FDA Approves First Sleep Apnea Medication, Offering Hope for Underserved Communities

Obesity

Trust in Medical Information Sources Varies by Race and Ethnicity

Latest News

Black Women Disproportionately Affected by Aggressive Endometrial Cancers

Gynecologic Cancer

Researchers found that Black patients more commonly had endometrial cancer of high-risk histology that was more aggressive than found in White women.

About Us

Editorial Policy

Contributors & Partners

eNewsletters

Contact Us

Work With Us

Advertising

GU Oncology Now

Blood Cancers Today

Cancer Nursing Today

DocWire News

MashupMD

Food Allergy Roundtable Discussions

Autoimmune Disease

Allergy

Blood Cancers

— Multiple Myeloma

Breast Cancer

Colorectal Cancer

Lung Cancer

Pancreatic Cancer

Prostate Cancer

Cancer

Diabetes

Heart Failure

Heart Disease Prevention

Heart Health

HIV Roundtable Discussions

COVID-19

Infectious Diseases

Asthma

COPD

Pulmonology

Digital Health

Workforce News

Public Health

Dermatology

Gastroenterology

Kidney Disease

Neurology

Pediatrics

Sickle Cell Disease

Eye Disease

Video Insights

More

Heart Disease in Women

Menopause

Reproductive Health

Women’s Neurology

Well Woman Today

Roundtables

Podcasts

Conferences

Viewpoints

Career Center

Subscribe