Patrick Daly

Urban Health Today

Study authors, led by Maria-Alexandra Papadimitriou, stated that the widely heterogeneous response to multiple myeloma (MM) treatments has limited providers&rsquo; abilities to accurately predict prognosis and individualize therapies. Papadimitriou and colleagues miRNA-sequenced patients with MM to identify potentially valuable prognostic markers.According to the report in the <a href="https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-023-04034-5" target="_blank" rel="noopener">Journal of Translational Medicine</a>, upregulation of miR-25 in CD138+ bone marrow plasma cells from patients with MM was a strong independent predictor for poor treatment response and disease progression among this population.<h3>miR-25 Plasma Levels Strongly Correlated With MM Outcomes</h3>Initially, researchers sequenced plasma cells from 24 patients with MM and 24 with smoldering MM (sMM) to characterize miRNA profiles. They then used in-house real-time-qPCR assays to assess levels of CD138+ and circulating miR-25 in CD138+ plasma cells from a screening cohort of 167 patients, of which 69 also had available MM peripheral plasma samples.Investigators found miR-25 in CD138+ plasma cells was upregulated for patients with MM versus sMM, Revised International Staging System (R-ISS) stage II/III versus R-ISS stage I disease, and progression versus no progression.In the screening cohort analysis, CD138+ miR-25 levels were associated with short-term progression (hazard ratio [HR], 2.729; P=.009) and poor survival (HR, 4.581; P=.004). The authors added that these findings were verified in 2 external validation cohorts with 760 (HR, 1.414; P=.039) and 149 patients (HR, 1.878; P=.005).Papadimitriou and colleagues ultimately suggested that pre-treatment miR-25 plasma levels effectively predict worse outcomes, &ldquo;serving as [a] potent non-invasive molecular tool in ameliorating MM patients&rsquo; risk-stratification and prognosis.&rdquo;Related:&nbsp;<a href="https://urbanhealthtoday.com/post/meta-analysis-the-significance-of-thrombosis-in-multiple-myeloma">The Significance of Thrombosis in Multiple Myeloma</a>

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Can miRNAs Predict MM Treatment Response?

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Study finds upregulation of CD138+ plasma miR-25 is significantly common and predicts poor treatment response in MM.

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