Valerie Christopher

Urban Health Today

<p>A new report using data from the Childhood Cancer Survivor Study (CCSS), presented at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting, evaluated breast cancer (BC) recurrence among childhood cancer survivors.<h2><strong>Breast Cancer Recurrence</strong></h2><p>In this study, female patients who participated in CCSS and had 5-year survival data were analyzed. These patients had been diagnosed with pathology-ascertained breast carcinomas (in situ or invasive) from 1981 to 2016. The investigators analyzed their disease against chronological period-specific National Comprehensive Cancer Network (NCCN) guidelines for primary BC.</p><p>Among the 431 childhood cancer survivors with subsequent BC (median age at diagnosis, 40 years), 68 had a recurrence of the disease. &nbsp;However, compared with matched control participants, survivors had similar 10-year recurrence risk (survivors, 14%; control participants, 12%; <em>P</em>=0.52).</p><p>Of the participants with BC recurrence, Hodgkin&rsquo;s lymphoma was the most common primary cancer diagnosis (63%).</p><p>Most patients (84%) received their first BC treatment in accordance with guidelines for primary BC. However, 47% underwent bilateral mastectomies (81% occurring prior to recurrence), 86% received chest radiotherapy, and 69% received anthracycline chemotherapy (69%) for either their primary childhood cancer or the first case of subsequent BC.</p><h2><strong>Mortality After Cancer Recurrence</strong></h2><p>Forty-eight patients died after BC recurrence, with 83% of the deaths related to BC and 11% due to cardiovascular causes. The probability of 10-year overall mortality was significantly higher among childhood cancer survivors (89%; 95% CI, 61%-97%) compared with control participants (42%; 95% CI, 18%-58%; <em>P</em>=0.0025). Survivors had an adjusted 2.6-fold (95% CI, 1.05-6.49) greater risk of death.</p><p>Although the risk for BC recurrence among childhood cancer survivors is similar to that for female patients with primary BC, this vulnerable group &ldquo;faces substantially greater mortality risk after recurrence,&rdquo; the authors wrote. They called for more research to identify early predictors of subsequent and recurrent BC among survivors of childhood cancers.</p></p>
<div class="post-references"><h3>References</h3><p>American Society of Clinical Oncology 2025 Annual Meeting. <a href="https://meetings.asco.org/abstracts-presentations/253402" target="_blank" rel="noopener">Abstract No. 10066</a></p>
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Childhood cancer survivors had a 2.6-fold higher risk of mortality after breast cancer recurrence.

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