Patrick Daly

Urban Health Today

Based on data from the CARTITUDE-1 trial, researchers suggested that ciltacabtagene autoleucel (cilta-cel) exhibited a comparable safety and efficacy profile in the treatment of patients with relapsed or refractory <a href="https://urbanhealthtoday.com/page/multiple-myeloma">multiple myeloma</a> (MM) either with or without prior allogeneic stem cell transplant (SCT).They noted patients who have received allogeneic SCT are commonly excluded from chimeric antigen receptor (CAR) T-cell trials, and data on treatment outcomes in these patients are sparse.&ldquo;Our findings add to the small body of evidence that will influence clinical decision-making with respect to treatment choices for patients with multiple myeloma who relapse following [allogeneic SCT],&rdquo; they summarized. The findings were presented in Clinical Lymphoma, Myeloma &amp; Leukemia.<h2>Cilta-cel Appears Unaffected by Prior Allogeneic SCT</h2>The analysis reviewed 97 patients with MM who received a <a href="https://www.fda.gov/media/156560/download">cilta-cel</a> infusion in CARTITUTDE-1, of whom 7 had previously received allogeneic SCT. The 7 patients had received a median of 9 previous lines of therapy (range, 6-14 lines), and their median time since undergoing transplantation was 5.1 years (range, 2.7-6.2 years).After a median follow-up of 27.7 months, the overall response rate among patients with prior transplantation was 85.7% (n=6). Between patients with and without prior allogeneic SCT, the rates of cytokine release syndrome were 85.7% versus 95.6%, and the rates of immune effector cell-associated neurotoxicity syndrome were 14.3% versus 16.7%, respectively.According to the report, there were no cases of graft-versus-host disease, although 1 patient with prior allogeneic SCT experienced grade 3 movement and neurocognitive treatment-emergent adverse events. Additionally, 1 patient died due to treatment-related lung abscess, and 1 died due to unrelated liver failure.Overall, the study&rsquo;s authors suggested that prior allogeneic SCT did not appear to compromise the safety or efficacy of cilta-cel in patients with relapsed or refractory MM enrolled in the CARTITUDE-1 trial.They did note that &ldquo;additional studies are needed to elucidate the effects of both host- and donor-derived CAR T cells to better understand treatment options for patients with multiple myeloma and other hematologic malignancies in the post-allogeneic SCT setting.&rdquo;&nbsp;Related: <a href="https://urbanhealthtoday.com/post/phase-2-results-of-teclistamab-in-relapsed-or-refractory-multiple-myeloma">Phase 2 Results of Teclistamab in Relapsed or Refractory Multiple Myeloma</a>

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Ciltacabtagene Autoleucel in Patients With MM and Prior SCT

Multiple Myeloma

Prior allogeneic stem cell transplantation did not appear to impact the safety and efficacy of cilta-cel treatment in patients with relapsed or refractory multiple myeloma.

Ciltacabtagene Autoleucel in Patients With MM and Prior SCT 

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