Rob Dillard

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A study analyzed gender diversity in leadership, funding, as well as authorship in US colon cancer clinical trials since 2000. The findings were presented at ACG 2024.
Researchers queried ClinicalTrials.gov from 2000 to 2023 using the search term “colon cancer,&#8221; and focused on completed or terminated U.S. studies. The findings yielded 1,355 trials, of which 1,346 were included in final analysis. The researchers noted that principal investigator (PI) and author gender were identified using pronouns or Genderize.io. The study data were analyzed using ANOVA, Chi-square tests, and t-tests.
The results found that colon cancer trial completion rates were higher for female PIs (84.7%) than male PIs (79.1%), while the rates were 73.7% for other genders, and 88.9% for mixed-gender groups. The findings further showed that trials led by mixed-gender groups lasted the longest (1521.6 days), followed by female-led (1467.3 days), male-led (1405.9 days), and other gender-led trials (1065.7 days). Female leadership grew at 0.3% per year (Regression P = 0.205). The investigators noted that funding disparities were evident: 44% from non-NIH/industry, 8.2% from NIH, and 2.6% from industry (ANOVA P < 0.005).

"Our review showed significant differences in CRC trials by PI gender. Trials led by female PI had a higher completion rate but longer duration of trial and lower journal metrics," the researchers concluded. They added that despite limitations in gender determination methodology "future efforts to further examine gender diversity and equity in research practices are warranted."

Reference
Amadi C, Jackson T, Agbim C, et al. Evaluating Gender Diversity in Colon Cancer Clinical Trial Leadership, Funding, and Authorship. Abstract #P0203. Presented at the American College of Gastroenterology 2024 Annual Scientific Meeting &#038; Postgraduate Course; October 25-30, Philadelphia, Pennsylvania.

Colon Cancer Clinical Trials Led by Women Have Higher Completion Rates

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A study analyzed gender diversity in leadership, funding, as well as authorship in US colon cancer clinical trials.

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