Tamara Thomas

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According to a study in Clinical Gastroenterology and Hepatology, distinctively different microbial signatures in the gut flora precede and predict Crohn’s disease recurrence in patients who achieve surgical remission.
The study, led by Dr. Cristian-Hernandez Rocha from the Department of Gastroenterology at the Pontificia Universidad Católica de Chile in Santiago, Chile, investigated the gut flora to understand the mechanism leading to intestinal inflammation in Crohn’s disease.
The researchers included 262 patients with Crohn’s disease undergoing surgery. The patients were primarily men, and the median age at surgery was 32 years.
Dr. Rocha and team analyzed about 944 tissues from about 349 cases of post-operative colonoscopy. They also extracted DNA from these samples and analyzed the genetic material of the bacteria living there.
The study showed that 97 patients showed remission in their first surgery (post-operative colonoscopy). Of these patients, about 25.8% developed recurrence, and the rest (74.2%) remained in remission at the second colonoscopy.
The findings also revealed a decreased level of the bacteria genus Anaerostipes at the biopsy sites in patients who experienced recurrence. Anaerostipes species produce short-chain fatty acids essential for gut homeostasis.
Conversely, there was an overgrowth of Gammaproteobacteria genera, such as Klebsiella and Escherichia-Shigella, bacteria linked to intestinal inflammation.
“Using several of the taxa positively and negatively associated with recurrence, we were able to improve the prediction of future endoscopic recurrence compared to known clinical risk factors of post-operative CD [Crohn’s disease] recurrences, such as smoking and anti-TNF prophylaxis,” the authors wrote.
Source:<a href="https://www.medscape.com/viewarticle/gut-flora-predicts-postoperative-crohns-diseas%20e-recurrence-2024a1000eqa"> Medscape</a>
Journal: <a href="https://www.sciencedirect.com/science/article/abs/pii/S1542356524005925">Clinical Gastroenterology and Hepatology</a>

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Gut Changes May Predict Crohn's Disease Recurrence

Gastroenterology

distinctively different microbial signatures in the gut flora precede and predict Crohn’s disease

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