Lou Portero

Urban Health Today

Early treatment with hydroxyurea (HU) may reverse cardiac remodeling and improve cardiac abnormalities in children and youth adults with sickle cell anemia, according to a study published on November 1st, 2021, in blood advances.Arushi Dhar and colleagues reviewed and analyzed the records of 100 patients with sickle who had a routine cardiac screening at Cohen Children&rsquo;s Medical Center between 2010 and 2017.Of the 100 patients, 60% were being treated with hydroxyurea, while 41.6% of the patients on hydroxyurea had been treated for less than a year. For patients treated with HU, the age when treatment began was statistically positively associated with left ventricular (LV) mass (p= 0.04) and tricuspid valve regurgitation velocity (TR) (P=0.02). Following analysis of the effect of treatment duration, patients treated with hydroxyurea for less than a year (LV end-diastolic diameter (LVEDd) z-score 2.24 &plusmn; 1.3 ) showed a significantly greater prevalence (P = 0.04) of left ventricular dilation compared with those who had been on treatment for more than one year (LVEDd z-score1.57 &plusmn; 1.1 ).&ldquo;The age at HU initiation was positively associated with LV mass and TR velocity,&rdquo; the authors write. &ldquo;This suggests that timely initiation of HU therapy may lead to reverse cardiac remodeling and improvement in these cardiac abnormalities before additional maladaptive changes set in.&rdquo;The authors disclosed no competing financial interests.&nbsp;Source: <a href="https://ashpublications.org/bloodadvances/article/5/21/4406/476912/Longitudinal-analysis-of-cardiac-abnormalities-in">Abstract/Full text</a>

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Early treatment with hydroxyurea (HU) may reverse cardiac remodeling and improve cardiac abnormalities in children and ...

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