Cailin Conner

AZUHT-PRODUCTIONwarmup

Allergy and Asthma Proceedings published a study that examined the effects of orexin-A, ghrelin, and leptin on sleep quality in patients with chronic spontaneous urticaria (CSU).
“Orexin-A, a neuroexcitatory peptide, plays a role in coordinating sleep-wake states,” the investigators explained, and while it has been established that sleep can be affected in patients with CSU, “the mechanisms of sleep regulation remain poorly understood.”
Thirty-three patients with CSU were compared with 34 sex- and age-matched healthy controls. Investigators measured serum levels of orexin-A, leptin, and ghrelin. Additionally, sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS). The Chronic Urticaria Quality-of-Life Questionnaire and Urticaria Activity Test (recorded over 7 consecutive days) were also utilized to gauge disease severity and its impact on patients’ lives.
Median serum levels of orexin-A and leptin were significantly higher in patients with CSU versus those in the control group, with orexin-A levels at 385.0 pg/mL (range, 90.0-495.0 pg/mL) and leptin levels at 3.1 ng/mL (range, 0.0-21.2 ng/mL). Conversely, there was no significant difference in the median serum ghrelin levels between the 2 groups.
Investigators also found a positive correlation between serum orexin-A levels and both ghrelin levels and sleep quality indicators. Specifically, higher orexin-A levels were associated with increased ghrelin levels (correlation coefficient [r], 0.298; P=.014), poorer sleep quality as measured by PSQI (r, 0.356; P=.003), and greater daytime sleepiness as indicated by ESS scores (r, 0.357; P=.003).
They concluded with a call for future studies to “elucidate the role of ghrelin and leptin on sleep quality in patients with CSU.”
Source: <a href="https://www.ingentaconnect.com/content/ocean/aap/2024/00000045/00000004/art00003;jsessionid=6786al52u66f1.x-ic-live-03" target="_blank" rel="noopener">Allergy and Asthma Proceedings</a>

Tamara Thomas

VA-Based Study Ties Lymphopenia to Worse Outcomes in Newly Diagnosed Multiple Myeloma

Multiple Myeloma

Yale Researchers Identify Potential Treatment for Endometriosis Inflammation

Reproductive Health

Black Women at Greater Risk of Dying from All Types of Breast Cancer

Breast Cancer Disparities

Latest News

Orexin-A Linked to Poor Sleep Quality in Patients With CSU

Chronic Spontaneous Urticaria

Elevated serum orexin-A levels are associated with poorer sleep quality in patients with chronic spontaneous urticaria.

About Us

Editorial Policy

Contributors & Partners

Contact Us

eNewsletters

Work With Us

Advertising

Career Center

GU Oncology Now

Blood Cancers Today

Cancer Nursing Today

DocWire News

MashupMD

Food Allergy Roundtable Discussions

Allergy

Blood Cancers

— Multiple Myeloma

Breast Cancer

Colorectal Cancer

Pancreatic Cancer

Prostate Cancer

Cancer

Diabetes

Gastroenterology

Heart Failure

Heart Disease Prevention

Heart Health

— Alzheimer’s Disease

Neurology

Public Health

Autoimmune Disease

Infectious Diseases

Obesity

Pediatrics

Sickle Cell Disease

Digital Health

Dermatology

Pulmonology

Video Insights

Workforce News

More

Gynecologic Cancer

Heart Disease in Women

Menopause

Women’s Neurology

Well Woman Today

Roundtables

Podcasts

Conferences

Viewpoints

Subscribe