Urban Health Today Editors

Urban Health Today

Non-Hispanic Black patients with lymphoma were less likely to receive autologous stem cell transplantation (ASCT) compared with non-Hispanic White patients, according to a recent <a href="https://pubmed.ncbi.nlm.nih.gov/34469069/">study</a>. However, the difference is partially explained by certain socioeconomic and disease-specific factors.&ldquo;Since [ASCT] is a potentially life-saving therapy for patients with lymphoma, it is important to understand whether disparities in treatment exist that might lead to inferior survival for minorities,&rdquo; study authors wrote.To explore possible disparities, they used data on 40,605 patients with lymphoma (4% Non-Hispanic Black and 84% Non-Hispanic White) from the Surveillance, Epidemiology, and End Results database. Included patients were aged 65 years or older and diagnosed with Hodgkin or non-Hodgkin lymphoma between 2008 and 2015.Autologous transplants were performed in 452 patients. The highest rate of transplant utilization occurred for mantle cell lymphoma, followed by T-cell, diffuse large B cell, and Hodgkin lymphoma.The median time from diagnosis to transplant was 1.0 years for non-Hispanic White patients, 0.6 years for non-Hispanic Black patients, 0.6 years for Asian patients, and 1.1 years for Hispanic patients.In an unadjusted model, non-Hispanic Black patients were 51% less likely to receive ASCT compared with non-Hispanic White patients (95% confidence interval [CI], 0.26-0.96; P=0.04). After adjusting for age at diagnosis and sex, the decreased likelihood increased to 61% (95% CI, 0.20-0.76; P=0.01).Once the researchers adjusted for socioeconomic and disease-specific factors the differences between non-Hispanic Black patients and non-Hispanic White patients was attenuated and became non-significant.&ldquo;Non-Hispanic Black patients were more than three times more likely to reside in the most economically distressed areas, and they had a higher comorbidity burden at the time of diagnosis,&rdquo; the researchers wrote. &ldquo;This suggests that racial/ethnic differences in [ASCT] utilization for lymphoma are partially explained by differences in these factors.&rdquo;The researchers noted no statistically significant differences between these two groups in the fully adjusted model.&ldquo;Our findings suggest that interventions to improve access to autologous transplantation should focus on reducing financial toxicity of transplantation and developing less toxic conditioning regimens for patients with comorbidities,&rdquo; the researchers wrote.

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Socioeconomic Factors, Comorbidities Explain Decreased Access to Transplant for Non-Hispanic Black Patients With Lymphoma

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Non-Hispanic Black patients with lymphoma were less likely to receive autologous stem cell transplantation (ASCT) ...

Socioeconomic Factors, Comorbidities Explain Decreased Access to Transplant for Blacks

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