Cailin Conner

Urban Health Today

The results of a study out of Catalonia, Spain, showed that treatment with statins led to the achievement of certain low-density lipoprotein cholesterol (LDL-C) goals and lower risk of coronary heart disease (CHD).
According to the investigators, “The effectiveness of statin treatment to reduce coronary events and mortality has hardly been examined considering goals of LDL-C.” Therefore, they conducted a retrospective cohort analysis to analyze secondary cardiovascular prevention through a comprehensive analysis of electronic health records from the Information System for the Development of Research in Primary Care database.
Patients aged 35 years and older who began statin treatment between 2006 and 2017 were included in the analysis. The study tracked these patients, encompassing a total of 54,175 participants, until the end of 2018.
The investigators categorized the achieved LDL-C levels into different goals—70-100 mg/dL, &lt;70-55 mg/dL, and &lt;55 mg/dL—and calculated the hazard ratios (HRs) for CHD for each group.
The mean age of participants was 69 years, and 37.2% (n=20,146) were female. Over the median follow-up period of 5.7 years, 10.5% (5687 patients) experienced CHD and 19.7% (10,676 patients) passed away.
The HRs for CHD were 0.86 (95% CI, 0.81-0.92) for the 70-100 mg/dL goal, 0.83 (95% CI, 0.76-0.90) for the &lt;70-55 mg/dL goal, and 0.80 (95% CI, 0.72-0.88) for the &lt;55 mg/dL goal. Additionally, the investigators assessed the impact of LDL-C reduction percentages, finding HRs of 0.89 (95% CI, 0.83-0.96) for a 30% to 40% reduction and 0.86 (95% CI, 0.8–0.93) for reductions between 40% to 50% and ≥50%.
The study did not find a significant association between LDL-C levels and all-cause mortality, suggesting that while statins are effective in reducing coronary events, their impact on overall mortality might be limited. Moreover, the analysis indicated no relevant differences in outcomes based on sex or age.
Source: <a href="https://onlinelibrary.wiley.com/doi/10.1111/eci.14258" target="_blank" rel="noopener">European Journal of Clinical Investigation</a>

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