Rob Dillard

Urban Health Today

Pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) and overall survival (OS) appear to vary by race/ethnicity when it comes to women with triple-negative breast cancer (TNBC), according to a study published in the Journal of Clinical Oncology.Researchers analyzed 40,890 women with TNBC who underwent NAC followed by surgery from the National Cancer Database (2010-2019). The primary outcomes were defined as pCR rates and OS based on race/ethnicity.Overall, 29.8% of patients demonstrated pCR. The investigators noted that the unadjusted OS was significantly higher for those with pCR compared with those with residual disease, and this correlation persisted after adjustment for demographic and tumor factors. The effect of achieving pCR on OS did not differ by race/ethnicity (interaction P=.10). However, non-Hispanic Black patients were less likely (odds ratio [OR], 0.89; 95% CI, 0.83-0.95; P=.001) and Hispanic patients were more likely (OR, 1.19; 95% CI, 1.08-1.31; P=.001) to achieve pCR than non-Hispanic White patients.&ldquo;Odds of achieving pCR and OS in patients with TNBC appear to be associated with race/ethnicity. Additional research is necessary to understand how race/ethnicity is associated with rates of pCR and OS, whether related to socioeconomic factors, biologic variables, or both,&rdquo; the researchers concluded.

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Study Finds Race-Based Disparities in pCR, OS in Patients With Triple-Negative Breast Cancer

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Pathologic complete response to neoadjuvant chemotherapy for TNBC and overall survival differ based on race/ethnicity. 

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