Study Finds Racial/Ethnic Differences in Plaque Psoriasis Treatment Efficacy

By Rob Dillard - Last Updated: January 11, 2023

There may exist differences in treatment efficacy for patients with plaque psoriasis based on race/ethnicity, according to a study published in Archives of Dermatological Research.

“Biologic medications have revolutionized treatment of psoriasis; however, there remains uncertainty in which medications should be used to maximize efficacy based on race/ethnicity,” said the investigators.

In this systematic review, researchers analyzed clinical trials focused on biologic treatment outcomes from inception of database until March 5th, 2021. The studies of interest provided data on racial/ethnic differences in biologic skin clearance efficacy using the Psoriasis Area and Severity Index (PASI) and “clear/almost clear” scores, the researchers noted. In total, the analysis comprised of 24 studies. The races/ethnicities included in these studies were Asian (n = 2740), White (n = 9745), Black (n = 138), and Latino (n = 728).

In terms of treatment efficacy, ixekizumab provided the highest “clear/almost clear” score (90.7%, 89.4%) and PASI 75 (98.8%, 96.6%) among Asian and Latino patients, guselkumab had the highest “clear/almost clear” score for White (86.8%) patients, while Black patients had highest “clear/almost clear” (75.0%) and PASI 75 (91.7%) scores to brodalumab, the investigators noted.

“For treatment of plaque psoriasis, there is evidence of differences in efficacy of biologics improving clinical disease severity between different races or ethnicities,” the researchers concluded.

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