Tamara Thomas

Urban Health Today

A study published in Brain Research found that regular aerobic exercise could significantly reduce disease markers like tau and amyloid proteins associated with Alzheimer’s disease.
Researchers have long explored the potential of physical activity in preventing Alzheimer’s disease. A recent study by scientists at the University of Bristol (UK) and the Federal University of São Paulo (Brazil) examined the benefits of exercise for individuals with Alzheimer’s disease. They also evaluated the relationship between hippocampal cell formation (essential for learning new information and memory) in sedentary and active individuals.
The researchers found that rats who completed a structured aerobic exercise program experienced a significant reduction in tau tangles (approximately 63%) and amyloid plaques (approximately 76%). Furthermore, iron accumulation in the brains of the exercising rodents decreased by approximately 58%. Iron naturally accumulates in the brain with age, especially after 60, and can negatively impact cognitive function.
In addition to its other benefits, the study found that exercise improved brain cell health and reduced brain inflammation in rodents (55% to 68%, depending on the inflammatory biomarker). Exercise also reduces cell death.
Furthermore, the researchers found that exercise improved communication between brain cells, restoring critical balance in the brain’s function as it ages.
“While physical exercise is known to reduce cognitive decline, the cellular mechanisms behind its neuroprotective effects have remained elusive- until now. This research highlights the potential for aerobic exercise to serve as a cornerstone in preventive strategies for Alzheimer’s,” said Dr. Augusto Coppi, Senior Lecturer in Veterinary Anatomy at the University of Bristol and one of the study’s senior authors.
The researchers recommend prioritizing exercise programs tailored to aging populations in public health initiatives and are now planning human clinical trials to confirm the protective effects observed in rodent models.
Source:<a href="https://www.sciencedaily.com/releases/2025/01/250115230749.htm"> Science Daily</a>
Journal:<a href="https://www.sciencedirect.com/science/article/abs/pii/S0006899324006747?via%3Dihub"> Brain Research</a>

Urban Health Today Editors

Dr. Bruce Dorr Discusses Hormone Replacement Therapy for Menopausal Women with BRCA1/2

Menopause

Many U.S. Adults are Unaware Alcohol, Diet, and Exercise Impact Risk for Colorectal Cancer

Colorectal Cancer

Circadian Rhythm Disruptions Linked to Higher Alzheimer’s Amyloid Levels in Brain

Alzheimer's & Dementia

Latest News

Study Suggests Aerobic Exercise Reduces Alzheimer's Disease Markers

Women's Neurology

Aerobic exercise has been found to reduce disease markers associated with Alzheimer’s disease and improve brain. Researchers recommend exercise programs tailored for aging adults.

About Us

Editorial Policy

Contributors & Partners

Contact Us

eNewsletters

Work With Us

Advertising

Career Center

GU Oncology Now

Blood Cancers Today

Cancer Nursing Today

DocWire News

MashupMD

Food Allergy Roundtable Discussions

Allergy

Blood Cancers

— Multiple Myeloma

Breast Cancer

Pancreatic Cancer

Prostate Cancer

Cancer

Diabetes

Gastroenterology

Heart Failure

Heart Disease Prevention

Heart Health

— Alzheimer’s Disease

Neurology

Public Health

Autoimmune Disease

Infectious Diseases

Obesity

Pediatrics

Sickle Cell Disease

Digital Health

Dermatology

Pulmonology

Video Insights

Workforce News

More

Gynecologic Cancer

Heart Disease in Women

Reproductive Health

Women’s Neurology

Well Woman Today

Roundtables

Podcasts

Conferences

Viewpoints

Subscribe