Rebecca Araujo

Urban Health Today

A study in JAMA Dermatology evaluated the components necessary to create a patient-centered definition of an atopic dermatitis (AD) flare.&ldquo;Flare is a term commonly used in AD care settings and clinical research, but little consensus exists on what it means,&rdquo; explained the investigators. &ldquo;Meanwhile, flare management is an important unmet research and treatment need.&rdquo;For this study, 657 adults with atopic dermatitis were surveyed, including 26 who completed focus groups. The primary measure was consensus on attributes of AD to include in a patient-centered definition of a flare. Patients rated statements from 1-9, with 1-3 being &ldquo;not important&rdquo; and 7-9 being &ldquo;critical to a flare definition.&rdquo; Consensus was defined as 70% of participants rating a statement as critical and less than 15% rating it as not important.Overall, 15 statements reached consensus from the focus group, and 12 reached consensus from the survey participants. The three statements with the highest agreement between survey participants were &ldquo;when my symptoms take significantly more of my attention than normal,&rdquo; &ldquo;a worsening of physical symptoms associated with AD,&rdquo; and &ldquo;a worsening of itching associated with AD.&rdquo; The statement &ldquo;acute worsening of symptoms of AD&rdquo;&nbsp;was ranked as the most important compared with the other statements.More than half (52.9%) of survey participants reported feeling aligned with their health care provider on what an AD flare is, and 77.6% reported that a patient-centered definition would help communicate to providers about their condition.&ldquo;While we achieved consensus on 12 statements using rigorous consensus cutoffs defined a priori, even statements with the highest agreement were not deemed as critical by every participant, and some statements that did not meet the consensus threshold were believed to be critical for some participants,&rdquo; the authors acknowledged. &ldquo;As such, [health care providers] should be aware that flare may not have the same meaning for each individual patient.&rdquo;The authors noted that their findings could be used to develop outcome measures focused on AD flares to measure treatment outcomes in this population.Source: <a href="https://jamanetwork.com/journals/jamadermatology/fullarticle/2823478" target="_blank" rel="noopener">JAMA Dermatology</a>

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