Jordana Jampel

Urban Health Today

In a new study <a href="https://link.springer.com/article/10.1245/s10434-024-16550-9">published</a> in Annals of Surgical Oncology, researchers used data from the Cancer Genome Atlas Colon Adenocarcinoma database to categorize White and Black patients with colon cancer based on disease stage and propensity-score match.Using these data, they investigated stage-specific transcriptional differences in tumor profiles of Black versus White patients. Differential gene expression and pathway enrichment analyses were performed for each stage. Logistic regression and quadratic discrimination analysis models were developed using consistently differentially expressed genes.Out of 247 patients, 128 had localized disease (22% Black), 81 had regional disease (84% Black), and 38 had distant disease (29% Black). Differential expression analysis revealed differences in 312 genes for localized disease, 105 for regional disease, and 199 for distant disease between Black and White patients.Pathway enrichment analysis revealed downregulation of the interleukin 17 pathway in Black patients with localized disease. In total, five genes exhibited race-specific transcriptional differences across all stages: RAMACL, POLR2J3, POLR2J2, MUC16, and PRSS21. Logistic regression and quadratic discriminant analysis model performance indicated that these genes represent racial differences (area under the receiver operating characteristic curve: 0.863 and 0.880).Reference:El Moheb M, Shen C, Kim S, et al. Stage-Specific Tumoral Gene Expression Profiles of Black and White Patients with Colon Cancer.&nbsp;Ann Surg Oncol. 2025;32(2):736-749. doi:10.1245/s10434-024-16550-9

Barry Greenberg, PhD

Julie Zissimopoulos, PhD

Van Ta Park, PhD, MPH

Monique Nugent, MD, MPH

Engaging Underrepresented Communities in Alzheimer’s Research

Alzheimer's & Dementia

Valerie Christopher

Racial Disparities Are Narrowing in Use of ERBB2-Targeted Therapies

Breast Cancer Disparities

Lou Portero

A Comprehensive Review of Trump's Most Favored Nation Drug Pricing Policy

Public Health

Latest News

Tumoral Gene Expression and Disease Stage in Black Vs White Patients With Colon Cancer

Colorectal Cancer

Researchers categorize White and Black patients with colon cancer based on disease stage and propensity-score match.

About Us

Editorial Policy

Contributors & Partners

Contact Us

eNewsletters

Work With Us

Advertising

Career Center

GU Oncology Now

Blood Cancers Today

Cancer Nursing Today

DocWire News

MashupMD

Food Allergy Roundtable Discussions

Allergy

Blood Cancers

— Multiple Myeloma

Breast Cancer

Pancreatic Cancer

Prostate Cancer

Cancer

Diabetes

Gastroenterology

Heart Failure

Heart Disease Prevention

Heart Health

— Alzheimer’s Disease

Neurology

Autoimmune Disease

Infectious Diseases

Obesity

Pediatrics

Sickle Cell Disease

Digital Health

Dermatology

Pulmonology

Video Insights

Workforce News

More

Gynecologic Cancer

Heart Disease in Women

Menopause

Reproductive Health

Women’s Neurology

Well Woman Today

Roundtables

Podcasts

Conferences

Viewpoints

Subscribe