Jordana Jampel

Urban Health Today

In a new study <a href="https://link.springer.com/article/10.1245/s10434-024-16550-9">published</a> in Annals of Surgical Oncology, researchers used data from the Cancer Genome Atlas Colon Adenocarcinoma database to categorize White and Black patients with colon cancer based on disease stage and propensity-score match.
Using these data, they investigated stage-specific transcriptional differences in tumor profiles of Black versus White patients. Differential gene expression and pathway enrichment analyses were performed for each stage. Logistic regression and quadratic discrimination analysis models were developed using consistently differentially expressed genes.
Out of 247 patients, 128 had localized disease (22% Black), 81 had regional disease (84% Black), and 38 had distant disease (29% Black). Differential expression analysis revealed differences in 312 genes for localized disease, 105 for regional disease, and 199 for distant disease between Black and White patients.
Pathway enrichment analysis revealed downregulation of the interleukin 17 pathway in Black patients with localized disease. In total, five genes exhibited race-specific transcriptional differences across all stages: RAMACL, POLR2J3, POLR2J2, MUC16, and PRSS21. Logistic regression and quadratic discriminant analysis model performance indicated that these genes represent racial differences (area under the receiver operating characteristic curve: 0.863 and 0.880).
Reference:
El Moheb M, Shen C, Kim S, et al. Stage-Specific Tumoral Gene Expression Profiles of Black and White Patients with Colon Cancer. Ann Surg Oncol. 2025;32(2):736-749. doi:10.1245/s10434-024-16550-9

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